Vancomycin-resistant Enterococcus infection

Infections caused by vancomycin-resistant strains of E. faecium or E. faecalis. More common in hospitalized patients with prolonged antibiotic therapy, immunosuppression, and vascular catheters.

ICD-10 B95.21 drug

Also known as: VRE infection, VRE bacteremia

Drugs used for this condition

ALinezolidFirst line · Oxazolidinone antibioticLinezolid is one of two main options for VRE infections alongside daptomycin. IDSA 2022 recommends linezolid for VRE-E. faecium bacteremia and urinary tract infections. In endocarditis, high-dose daptomycin with ceftaroline is preferred. The drug is active against both resistance gene types (vanA and vanB), and 100% oral bioavailability simplifies step-down therapy.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit