Vitamin B6 (pyridoxine) deficiency

Reduced pyridoxal-5-phosphate in plasma. Develops with isoniazid, hydralazine, or penicillamine therapy, in patients with chronic alcohol use, and in older adults with nutritional deficiency. Presents with peripheral neuropathy, seborrhoeic dermatitis, glossitis, and in infants with seizures.

ICD-10 E53.11 drug

Also known as: Hypopyridoxinosis

Drugs used for this condition

APyridoxine (vitamin B6)First line · Vitamins. CoenzymePyridoxine 25–100 mg daily is first-line for confirmed vitamin B6 deficiency in adults. In patients on isoniazid (drug-induced neuropathy prevention): 25–50 mg daily concurrent pyridoxine. In patients on penicillamine, hydralazine, or cycloserine: similar doses. In infants with pyridoxine-dependent epilepsy: high-dose lifelong therapy.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit