MinorXanthine oxidase inhibitors×Selective COX-2 inhibitor (coxib)
Updated · Methodology
Mechanism
Each occupies a different place in gout treatment: allopurinol lowers urate long term while etoricoxib quells flare inflammation. Neither label names the other substance in its interactions section, and allopurinol reserves its warnings for azathioprine, mercaptopurine and coumarin anticoagulants.
Symptoms
The pair produces no distinct picture. Watch each one separately: skin rash when starting allopurinol, which requires stopping it, and from etoricoxib high blood pressure, oedema and gastric discomfort.
Management
Allopurinol started during a flare can prolong it, which is why it is combined with anti-inflammatory or colchicine cover for the first months. If allopurinol was already being taken before the attack, it is not interrupted: stopping it shifts urate and lengthens the flare. Etoricoxib is withdrawn once inflammation settles.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- AEMPS: Ficha técnica Etoricoxib Cinfa 120 mg comprimidos recubiertos con película EFG (2023)– AEMPS, CIMA, nº registro 80754, secciones 4.4 y 4.5
- AEMPS: Ficha técnica Alopurinol Cinfa 100 mg comprimidos EFG (2024)– AEMPS, CIMA, nº registro 63480, sección 4.5