Critical
Amiodarone × Ziprasidone
Class III antiarrhythmics (Vaughan Williams)×Atypical antipsychotic – indole derivative
Mechanism
Ziprasidone prolongs QT clinically (15-20 ms). With amiodarone – torsades de pointes.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.