ModerateHMG-CoA reductase inhibitors (statins)×Fluoroquinolone antibacterials
Updated · Methodology
Mechanism
Ciprofloxacin is a weak CYP3A4 inhibitor. Atorvastatin plasma levels may rise slightly during short ciprofloxacin courses.
Symptoms
Usually no changes. In patients with myopathy risk factors: rare muscle pain.
Management
For short ciprofloxacin courses (5–7 days), no special adjustment. In patients with myopathy risk factors, check creatine kinase on muscle symptoms.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Cipro (ciprofloxacin hydrochloride) prescribing information (2016)– ; DailyMed setid 888dc7f9-ad9c-4c00-8d50-8ddfd9bd27c0
- AEMPS: Ficha técnica: Atorvastatina (nº registro 69536), sección 4.5 (2024)– AEMPS, CIMA, nº registro 69536, sección 4.5