CriticalAntiviral, nucleoside analogue×Antineoplastic, oral prodrug of 5-FU
Updated · Methodology
Mechanism
Capecitabine is a 5-FU prodrug, same fatal mechanism via brivudine DPD inhibition.
Symptoms
Severe myelosuppression, grade III hand-foot syndrome, mucositis, diarrhoea.
Management
Combination contraindicated. Minimum 4-week washout.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Xeloda (capecitabine) SmPC (2024)– EMA EPAR Xeloda