ModerateInhaled corticosteroids (ICS)×Estrogens. Natural and semisynthetic estrogens, plain
Updated · Methodology
Mechanism
Oestrogens raise corticosteroid-binding globulin, increasing the bound budesonide fraction, but the effective free fraction changes minimally. The interaction is clinically minor.
Symptoms
No specific clinical manifestations. On systemic long-term therapy, both drugs' side effects may appear.
Management
No dose adjustment needed. In women on combined oral contraceptives and oral budesonide, check BP and weight every 3 months. With significant systemic budesonide side effects, consider switching to inhaled glucocorticoids or mesalazine.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
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Sources
- FDA: Pulmicort (budesonide) prescribing information (2010)– ; DailyMed setid ae1105cd-69fc-4c15-937f-c535304341c2