MajorAngiotensin II receptor blocker×Non-steroidal anti-inflammatory drugs (NSAIDs)
Updated · Methodology
Mechanism
Similar to ibuprofen + losartan. Diclofenac has a high nephrotoxic potential among NSAIDs.
Symptoms
Reduced urine output, rising creatinine and potassium, oedema. Symptoms appear earlier in older patients and in chronic kidney disease.
Management
Avoid prolonged combination. If diclofenac is needed for a short course, use the minimum effective dose for 5–7 days with creatinine monitoring. For chronic analgesia: paracetamol or celecoxib.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Diclofenac potassium tablet (Advagen Pharma Ltd) – Prescribing Information (2009)– ; DailyMed setid 82218d5c-1625-471a-aabe-f43338e5176b
- AEMPS: Ficha técnica: Candesartán (nº registro 74775), sección 4.5 (2025)– AEMPS, CIMA, nº registro 74775, revisión 03/2025, sección 4.5