MajorAntiepileptics. Carboxamide derivatives×Direct thrombin inhibitor
Updated · Methodology
Mechanism
Carbamazepine induces P-glycoprotein, the main dabigatran clearance route. Dabigatran plasma levels fall and anticoagulant effect weakens – stroke risk in atrial fibrillation rises.
Symptoms
The patient feels nothing. Stroke, deep vein thrombosis, and pulmonary embolism risks rise.
Management
Avoid the combination. Alternative anticoagulants: warfarin with INR monitoring or low molecular weight heparin for short courses. Alternative anticonvulsants without induction: levetiracetam, lamotrigine.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Pradaxa (dabigatran etexilate) prescribing information (2015)– ; DailyMed setid ba74e3cd-b06f-4145-b284-5fd6b84ff3c9
- AEMPS: Ficha técnica: Dabigatrán etexilato (nº registro 86841), sección 4.5 (2026)– AEMPS, CIMA, nº registro 86841, sección 4.5
- AEMPS: Ficha técnica: Carbamazepina (nº registro 62621), sección 4.5 (2025)– AEMPS, CIMA, nº registro 62621, sección 4.5