MajorAngiotensin-converting enzyme inhibitors (ACEi)×Antibacterial, dihydrofolate reductase inhibitor
Updated · Methodology
Mechanism
Dual K+-sparing effect: enalapril suppresses aldosterone, trimethoprim blocks ENaC. Hyperkalaemia.
Symptoms
Hyperkalaemia within 5 days.
Management
Check K+ and creatinine on day 5. Alternative – fosfomycin or nitrofurantoin for UTI.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →