MinorVitamins. Haemopoietic stimulants×Biguanides. Oral antihyperglycemic agents
Updated · Methodology
Mechanism
Metformin on long-term use (over 5 years) moderately reduces blood B12 (by 10–30%). Effect on folate is minimal. Folate deficiency on metformin has not been described.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
No folate dose adjustment needed. On long-term metformin, check B12 yearly. For pregnancy planning in women with diabetes, folic acid 400–800 mcg/day is standard regardless of metformin.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
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Medicine list: everything you take in one place →