MajorNon-steroidal anti-inflammatory drugs (NSAIDs)×NSAID, propionic acid derivative
Updated · Methodology
Mechanism
Both are NSAIDs blocking the same enzyme, so analgesia does not add up the way harm does. The ibuprofen label is blunt: simultaneous use with other NSAIDs should be avoided, since it can increase the risk of gastrointestinal ulcer and bleeding. Naproxen's long half-life keeps inhibition running for hours after the last dose, so the overlap is real even with spaced dosing.
Symptoms
Black or tarry stools, coffee-ground vomit, epigastric pain that food does not settle. Ankle oedema, reduced urine output, rising blood pressure and creatinine follow. Over 65, with prior ulcer, anticoagulants or corticosteroids, bleeding may be the first sign.
Management
Keep a single NSAID. If naproxen is not enough, reinforce with paracetamol or metamizole rather than adding ibuprofen. If both have already been taken, stop one and keep gastric protection where risk factors exist; black stools or coffee-ground vomit call for urgent assessment.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- AEMPS: Ficha técnica Ibuprofeno Cinfa 600 mg comprimidos recubiertos con película EFG (2024)– AEMPS, CIMA, nº registro 70039, secciones 4.4 y 4.5
- AEMPS: Ficha técnica Naproxeno Normon 500 mg comprimidos EFG (2024)– AEMPS, CIMA, nº registro 68435, sección 4.5