MajorAntifungal, triazole×Synthetic opioid, full mu-receptor agonist
Updated · Methodology
Mechanism
Strong CYP3A4 inhibitor. Methadone rises 2-3 fold.
Symptoms
Sedation, respiratory depression, QT prolongation.
Management
Reduce methadone by 25%, ECG monitoring.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Methadone hydrochloride tablets (SpecGx) – Prescribing Information (2014)
- AEMPS: Ficha técnica: Metadona (nº registro 62423), sección 4.5 (2026)– AEMPS, CIMA, nº registro 62423, sección 4.5
- AEMPS: Ficha técnica: Itraconazol (nº registro 65775), sección 4.5 (2026)– AEMPS, CIMA, nº registro 65775, revisión 04/2026, sección 4.5