Major
Itraconazole × Methadone
Antifungal, triazole×Synthetic opioid, full mu-receptor agonist
Mechanism
Strong CYP3A4 inhibitor. Methadone rises 2-3 fold.
Symptoms
Sedation, respiratory depression, QT prolongation.
Management
Reduce methadone by 25%, ECG monitoring.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.