MajorSystemic antimycotics. Imidazole derivatives×Calcineurin inhibitor (immunosuppressant)
Updated · Methodology
Mechanism
Strong CYP3A4 inhibitor – tacrolimus rises 4-5 fold.
Symptoms
Nephrotoxicity.
Management
Reduce tacrolimus by 75%.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Prograf (tacrolimus) section 7 (2013)– ; DailyMed setid 7f667de1-9dfa-4bd6-8ba0-15ee2d78873b
- AEMPS: Ficha tecnica de Prograf (tacrolimus) (2024)– AEMPS CIMA, 2024
- AEMPS: Ficha técnica: Tacrolimus (nº registro 84607), sección 4.4 (2026)– AEMPS, CIMA, nº registro 84607, revisión 03/2026, sección 4.4