CriticalSelective serotonin reuptake inhibitor (SSRI)×Antidepressant, irreversible non-selective monoamine oxidase inhibitor (MAO-A and MAO-B)
Updated · Methodology
Mechanism
Paroxetine is an SSRI with additional antimuscarinic activity. Combined with phenelzine causes serotonin syndrome plus additive sedation.
Symptoms
Hyperthermia, myoclonus, tachycardia, marked sedation.
Management
Combination contraindicated. 2-week washout.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Nardil (phenelzine sulfate) prescribing information (2009)– FDA Nardil label, Section 4 Contraindications; DailyMed setid 513a41d0-37d4-4355-8a6d-a2c643bce6fa
- AEMPS: Ficha técnica: Paroxetina (nº registro 66932), sección 4.3 (2025)– AEMPS, CIMA, nº registro 66932, revisión 12/2025, sección 4.3