CriticalClass III antiarrhythmics (Vaughan Williams)×First-generation antipsychotic, butyrophenone. Used as antiemetic.
Updated · Methodology
Mechanism
Dual QT prolongation (amiodarone 30-50 ms, droperidol 10-20 ms). FDA boxed warning on droperidol.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Combination contraindicated. Alternative – low-dose ondansetron or metoclopramide.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Inapsine (droperidol) prescribing information (2007)– FDA Inapsine label, boxed warning QT