Critical
Droperidol × Sotalol
First-generation antipsychotic, butyrophenone. Used as antiemetic.×Non-selective beta blocker with class III antiarrhythmic activity
Mechanism
Dual QT prolongation.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- FDA: Inapsine (droperidol) prescribing information (2007)– FDA Inapsine label, boxed warning QT