CriticalClass Ia antiarrhythmic (sodium channel blocker with intermediate kinetics)×Non-selective beta blocker with class III antiarrhythmic activity
Updated · Methodology
Mechanism
Additive QT prolongation (sotalol extends 30 ms, quinidine 20–40 ms). Torsades de pointes.
Symptoms
Syncope, torsades de pointes.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- DailyMed: Quinidine: FDA prescribing information, Drug Interactions section (DailyMed) (2024)
- AEMPS: Ficha técnica: Sotalol (nº registro 89413), sección 4.5 (2024)– AEMPS, CIMA, nº registro 89413, revisión 03/2024, sección 4.5