CriticalClass III antiarrhythmics (Vaughan Williams)×Non-selective beta blocker with class III antiarrhythmic activity
Updated · Methodology
Mechanism
Both strongly prolong QT (amiodarone 30-50 ms, sotalol 30 ms). Additive prolongation – torsades de pointes.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Combination contraindicated. Choose one antiarrhythmic.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Amiodarone hydrochloride tablet (Dr. Reddy's Labratories Inc.) – Prescribing Information (2018)– ; DailyMed setid 95cef33b-c0e6-b17c-7cbb-f5c066872705
- FDA: Betapace (sotalol) prescribing information – QT and antiarrhythmic interactions (2011)– FDA Betapace label, Contraindications §4 and Warnings §5; DailyMed setid a6a7702f-36c9-45db-b640-453dc324baee
- DailyMed: Sotalol: FDA prescribing information, Drug Interactions section (DailyMed) (2024)
- AEMPS: Ficha técnica: Sotalol (nº registro 89413), sección 4.5 (2024)– AEMPS, CIMA, nº registro 89413, revisión 03/2024, sección 4.5