Major
citalopram × Sotalol
SSRI (selective serotonin reuptake inhibitor)×Non-selective beta blocker with class III antiarrhythmic activity
Mechanism
Sotalol + citalopram – additive QT prolongation.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Cap citalopram at 20 mg/day in elderly. ECG monitoring.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.