Critical
Sotalol × Ziprasidone
Non-selective beta blocker with class III antiarrhythmic activity×Atypical antipsychotic – indole derivative
Mechanism
Dual QT prolongation, torsades risk.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.