Critical
Moxifloxacin × Ziprasidone
Fourth-generation fluoroquinolone×Atypical antipsychotic – indole derivative
Mechanism
Dual QT prolongation (ziprasidone 15-20 ms + moxifloxacin 10-20 ms). Torsades de pointes.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.