CriticalFourth-generation fluoroquinolone×Atypical antipsychotic – indole derivative
Updated · Methodology
Mechanism
Dual QT prolongation (ziprasidone 15-20 ms + moxifloxacin 10-20 ms). Torsades de pointes.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Geodon (ziprasidone) prescribing information (2009)
- AEMPS: Ficha técnica: Ziprasidona (nº registro 80960), sección 4.3 (2025)– AEMPS, CIMA, nº registro 80960, revisión 05/2025, sección 4.3