MajorFirst-generation antipsychotic, aliphatic-side-chain phenothiazine×Fourth-generation fluoroquinolone
Updated · Methodology
Mechanism
Additive QT prolongation.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Alternative – levofloxacin.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Thorazine (chlorpromazine) prescribing information (2014)– FDA Thorazine label