Critical
Amiodarone × Chlorpromazine
Class III antiarrhythmics (Vaughan Williams)×First-generation antipsychotic, aliphatic-side-chain phenothiazine
Mechanism
Dual QT prolongation, additive hypotension (chlorpromazine alpha-1 block).
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- FDA: Thorazine (chlorpromazine) prescribing information (2014)– FDA Thorazine label