Major
Amiodarone × Propafenone
Class III antiarrhythmics (Vaughan Williams)×Class Ic antiarrhythmic with beta-blocking activity
Mechanism
Additive AV node slowing and QT prolongation. Bradycardia, AV block.
Symptoms
Bradycardia below 50, AV block.
Management
Avoid combination. Choose one antiarrhythmic.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- FDA: Rythmol (propafenone) prescribing information (2013)– FDA Rythmol label