MajorClass III antiarrhythmics (Vaughan Williams)×Class Ic antiarrhythmic with beta-blocking activity
Updated · Methodology
Mechanism
Additive AV node slowing and QT prolongation. Bradycardia, AV block.
Symptoms
Bradycardia below 50, AV block.
Management
Avoid combination. Choose one antiarrhythmic.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Rythmol (propafenone) prescribing information (2013)– FDA Rythmol label