MajorCardiac glycosides (digitalis)×Class Ic antiarrhythmic with beta-blocking activity
Updated · Methodology
Mechanism
Propafenone inhibits renal P-glycoprotein. Digoxin rises 50-75%.
Symptoms
Nausea, yellow vision, bradycardia.
Management
Reduce digoxin by 50%, check level on day 5.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Rythmol (propafenone) prescribing information (2013)– FDA Rythmol label
- AEMPS: Ficha técnica: Digoxina (nº registro 34753), sección 4.5 (2026)– AEMPS, CIMA, nº registro 34753, revisión 02/2026, sección 4.5