ModerateClass III antiarrhythmics (Vaughan Williams)×Selective COX-2 inhibitor (coxib)
Updated · Methodology
Mechanism
Celecoxib is a CYP2C9 substrate. Amiodarone weakly inhibits CYP2C9, so celecoxib AUC may rise moderately. Clinically significant amplification of celecoxib side effects is unlikely.
Symptoms
Possible typical celecoxib side effects: dyspepsia, peripheral oedema, BP rise. GI bleeding is rare.
Management
No dose adjustment needed. On long-term celecoxib, check BP and renal function every 3 months. Alternatives for rheumatologic pain: topical NSAIDs, paracetamol up to 2 g/day.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Amiodarone hydrochloride tablet (Dr. Reddy's Labratories Inc.) – Prescribing Information (2018)– ; DailyMed setid 95cef33b-c0e6-b17c-7cbb-f5c066872705
- AEMPS: Ficha técnica: Celecoxib (nº registro 78687), sección 4.5 (2024)– AEMPS, CIMA, nº registro 78687, revisión 07/2024, sección 4.5