MajorSelective COX-2 inhibitor (coxib)×Angiotensin II receptor blockers (sartans)
Updated · Methodology
Mechanism
Similar to enalapril + celecoxib. NSAIDs reduce renal blood flow; the ARB (losartan) lowers glomerular pressure. The combination causes acute kidney injury.
Symptoms
Reduced urine output, rising creatinine and potassium, oedema. Symptoms appear earlier in older patients and in chronic kidney disease.
Management
For prolonged celecoxib therapy, check creatinine 2–4 weeks after start, then every 3 months. In older patients and chronic kidney disease, paracetamol is preferable.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Cozaar (losartan) section 7 (2018)– ; DailyMed setid 9949448f-c3b9-44ee-94ed-c1aca8c90f39
- AEMPS: Ficha técnica: Celecoxib (nº registro 78687), sección 4.5 (2024)– AEMPS, CIMA, nº registro 78687, revisión 07/2024, sección 4.5
- AEMPS: Ficha técnica: Losartan (nº registro 67729), sección 4.5 (2025)– AEMPS, CIMA, nº registro 67729, revisión 03/2025, sección 4.5