Major
Escitalopram × Moxifloxacin
Selective serotonin reuptake inhibitors (SSRIs)×Fourth-generation fluoroquinolone
Mechanism
Additive QT prolongation.
Symptoms
QTc above 500 ms, syncope, torsades de pointes risk.
Management
Alternative – levofloxacin or other class.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- FDA: Avelox (moxifloxacin) prescribing information – QT prolongation warning (2016)– FDA Avelox label, Warnings and Precautions §5.7 – avoid with QT-prolonging drugs
- BNF: BNF – Escitalopram interactions (2024)