MinorClass III antiarrhythmics (Vaughan Williams)×Leukotriene receptor antagonists
Updated · Methodology
Mechanism
No clinically significant direct interaction. Montelukast is metabolised by CYP2C8 and CYP3A4; amiodarone moderately inhibits CYP3A4. Montelukast AUC may rise slightly, without clinical consequences.
Symptoms
The combination usually causes no specific symptoms. Each drug's individual side effects remain.
Management
No dose adjustment needed. In asthma with atrial fibrillation, the combination is standard.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
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Sources
- FDA: Amiodarone hydrochloride tablet (Dr. Reddy's Labratories Inc.) – Prescribing Information (2018)– ; DailyMed setid 95cef33b-c0e6-b17c-7cbb-f5c066872705