CriticalClass III antiarrhythmics (Vaughan Williams)×Atypical antipsychotic, selective 5-HT2A inverse agonist
Updated · Methodology
Mechanism
Additive QT prolongation (amiodarone 30-50 ms, pimavanserin 5-8 ms). FDA recommends avoiding.
Symptoms
QT above 500 ms, torsades de pointes.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Nuplazid (pimavanserin) prescribing information (2023)– FDA Nuplazid label