MajorCalcium channel blockers (dihydropyridines)×Class III antiarrhythmic
Updated · Methodology
Mechanism
Dronedarone is a strong CYP3A4 inhibitor, the main amlodipine metabolic route. Amlodipine plasma levels may double.
Symptoms
Blood pressure drop: postural dizziness, syncope. Ankle oedema (typical of amlodipine), facial flushing, reflex tachycardia are possible.
Management
Cap amlodipine at 5 mg/day when combined. Alternative calcium channel blocker: diltiazem (with caution combined with an antiarrhythmic), or replace amlodipine with an ACE-I/ARB.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Multaq (dronedarone) prescribing information (2020)– ; DailyMed setid 7fa41601-7fb5-4155-8e50-2ae903f0d2d6
- AEMPS: Ficha técnica: Amlodipino (nº registro 65461), sección 4.5 (2025)– AEMPS, CIMA, nº registro 65461, revisión 08/2025, sección 4.5
- AEMPS: Ficha técnica: Dronedarona (nº registro 84320), sección 4.5 (2025)– AEMPS, CIMA, nº registro 84320, revisión 10/2025, sección 4.5