ModerateCalcium channel blockers (dihydropyridines)×Organic nitrate
Updated · Methodology
Mechanism
Additive hypotension with sublingual or parenteral nitroglycerin. Both drugs are vasodilators (amlodipine – calcium channel blocker, nitroglycerin – nitrate vasodilator).
Symptoms
Lower blood pressure, postural dizziness, fatigue. Older patients: fall risk.
Management
The combination is acceptable in angina. The patient takes the first nitroglycerin dose sitting or lying down. Older patients: fall risk after nitroglycerin. Advise the patient to consult a clinician with frequent episodes.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Verapamil hydrochloride tablet (Zydus Lifesciences Limited) – Prescribing Information (2017)– ; DailyMed setid 051392d3-8ec1-450c-8c38-791d4ef1a2db