CriticalOrganic nitrate×Soluble guanylate cyclase (sGC) stimulator
Updated · Methodology
Mechanism
Riociguat activates sGC independently of NO. Nitrate adds NO – synergistic systemic hypotension. FDA Section 4.3.
Symptoms
Severe hypotension.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Adempas (riociguat) SmPC, Section 4.3 (2024)– EMA EPAR Adempas
- AEMPS: Ficha técnica: Nitroglicerina (nº registro 60314), sección 4.3 (2025)– AEMPS, CIMA, nº registro 60314, revisión 09/2025, sección 4.3