ModerateBenzodiazepines. Short-to-medium-acting anxiolytics×Organic nitrate
Updated · Methodology
Mechanism
Additive hypotension with sublingual nitroglycerin. Alprazolam sedation may worsen dizziness.
Symptoms
Lower blood pressure, postural dizziness, fatigue. Older patients: fall risk.
Management
The patient takes the first nitroglycerin dose sitting or lying down. Warn the patient about fall risk after nitroglycerin while on alprazolam.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Xanax (alprazolam) prescribing information (2016)– ; DailyMed setid 388e249d-b9b6-44c3-9f8f-880eced0239f