MajorDirect oral anticoagulants (factor Xa inhibitors)×Antiretroviral, non-nucleoside reverse transcriptase inhibitor (NNRTI)
Updated · Methodology
Mechanism
Efavirenz induces CYP3A4 and P-gp. Apixaban falls 50% – stroke risk in AF.
Symptoms
Ischemic stroke or recurrent VTE.
Management
Alternative ARV – dolutegravir, or alternative anticoagulant – warfarin with INR 2.5-3.5.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Eliquis prescribing information (2021)
- AEMPS: Ficha técnica de Eliquis 5 mg comprimidos recubiertos con película (apixabán) (2026)– AEMPS, CIMA (texto EMA), nº registro 111691009, secciones 4.4 y 4.5