MajorAntiretroviral, non-nucleoside reverse transcriptase inhibitor (NNRTI)×HMG-CoA reductase inhibitors (statins)
Updated · Methodology
Mechanism
Efavirenz induces CYP3A4. Simvastatin falls 60% – lipid-lowering effect lost.
Symptoms
LDL returns to baseline.
Management
Alternative statin – pravastatin or rosuvastatin.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- AEMPS: Ficha tecnica de Sustiva (efavirenz) (2024)– AEMPS CIMA, 2024