MajorDirect oral anticoagulants (factor Xa inhibitors)×Antitubercular, rifamycin derivative
Updated · Methodology
Mechanism
Rifabutin is a moderate CYP3A4 + P-gp inducer (2-3 fold weaker than rifampicin). Apixaban falls 30-40%. Lower risk than with rifampicin but still significant.
Symptoms
Reduced anticoagulation, thrombosis risk.
Management
If possible – warfarin to INR 2.0-3.0.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Mycobutin (rifabutin) prescribing information (2018)– FDA Mycobutin label
- AEMPS: Ficha técnica de Eliquis 5 mg comprimidos recubiertos con película (apixabán) (2026)– AEMPS, CIMA (texto EMA), nº registro 111691009, secciones 4.4 y 4.5