MajorMacrolide antibiotic×Antitubercular, rifamycin derivative
Updated · Methodology
Mechanism
Clarithromycin inhibits CYP3A4. Rifabutin rises 2.5-fold – increased uveitis risk, especially in MAC infection patients.
Symptoms
Eye pain, photophobia, reduced vision.
Management
Reduce rifabutin to 300 mg/day (standard 450 mg). Regular ophthalmology review.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Mycobutin (rifabutin) prescribing information (2018)– FDA Mycobutin label
- AEMPS: Ficha técnica: Claritromicina (nº registro 75638), sección 4.5 (2025)– AEMPS, CIMA, nº registro 75638, sección 4.5