Evigrade
ModerateDietary supplements, plant adaptogens (local classification)×Hypnotics. Melatonin receptor agonists

Updated · Methodology

Mechanism

Both are taken at night and for the same reason, so they end up in the same regimen easily. Ashwagandha has sedative activity of its own and melatonin advances sleep onset; together, next-morning residual drowsiness exceeds either one alone.

Symptoms

Morning drowsiness, a foggy head, slower reactions at the wheel. In older people, a higher risk of falling when getting up at night.

Management

Try one thing at a time for two weeks before adding the other: one is almost always enough. If both are kept, start with the lower melatonin dose and avoid early-morning driving until tolerance is clear.

Check the full regimen, not just this pair

Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.

Open checker

Summary of a multi-drug list →

Medicine list: everything you take in one place →

Sources

Other interactions with Ashwagandha (Withania somnifera)