MajorAntiretroviral, HIV protease inhibitor×HMG-CoA reductase inhibitors (statins)
Updated · Methodology
Mechanism
Atazanavir inhibits CYP3A4. Atorvastatin rises 8-fold – rhabdomyolysis risk.
Symptoms
Myalgia, weakness, dark urine, rising CK within 5-10 days.
Management
Cap atorvastatin at 10 mg/day. Better – pravastatin 40 mg.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Lipitor (atorvastatin) prescribing information, Section 7 Drug Interactions (2017)
- AEMPS: Ficha técnica: Atorvastatina (nº registro 69536), sección 4.5 (2024)– AEMPS, CIMA, nº registro 69536, sección 4.5