Moderate
Atorvastatin × Pantoprazole
HMG-CoA reductase inhibitors (statins)×Proton pump inhibitors
Mechanism
Pantoprazole is the most CYP-neutral PPI. No clinically significant interaction with statins.
Symptoms
No changes.
Management
The combination is acceptable without dose change. Pantoprazole is the preferred PPI in patients on statins and other CYP3A4-dependent drugs.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.