ModerateSelective beta-adrenergic blockers×First-generation antipsychotics. Butyrophenone derivatives
Updated · Methodology
Mechanism
Additive hypotension (haloperidol blocks α1-adrenoceptors) and QT prolongation risk (haloperidol is a known QT prolonger).
Symptoms
Lower blood pressure, postural dizziness, syncope. ECG: QT prolongation. Older patients: fall risk.
Management
Avoid the combination, especially parenteral haloperidol. Alternative antipsychotics with minimal α1 and QT effect: olanzapine or aripiprazole. For acute delirium: dexmedetomidine.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Haloperidol tablet (Ajanta Pharma USA Inc.) – Prescribing Information (2008)– ; DailyMed setid 31e33656-2f53-49e6-9816-261ea2e6961a