ModerateInhaled corticosteroids (ICS)×Estrogens — natural and semisynthetic
Updated · Methodology
Mechanism
Oestradiol raises corticosteroid-binding globulin, increasing the bound budesonide fraction. The free fraction changes minimally. The interaction is clinically minor.
Symptoms
No specific clinical manifestations. On long-term systemic therapy, both drugs' side effects may appear.
Management
No dose adjustment needed. In women on menopausal hormone therapy and oral budesonide, check BP, weight, and lipid profile every 6 months. With systemic budesonide over 3 months, consider switching to inhaled glucocorticoids.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Pulmicort (budesonide) prescribing information (2010)– ; DailyMed setid ae1105cd-69fc-4c15-937f-c535304341c2