MajorOther antidepressants (NDRI)×SNRI
Updated · Methodology
Mechanism
Additive seizure threshold reduction plus elevated synaptic norepinephrine (bupropion is a norepinephrine-dopamine reuptake inhibitor; duloxetine is an SNRI). Tachycardia and hypertension may emerge.
Symptoms
Tachycardia, hypertension, tremor, agitation. Seizures may occur, especially with prior epilepsy or eating disorders.
Management
The combination is possible for antidepressant augmentation with careful blood pressure and pulse monitoring. Cap bupropion at 300 mg and duloxetine at 60 mg/day. Avoid with prior epilepsy or eating disorders.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Wellbutrin (bupropion hydrochloride) prescribing information (2017)– ; DailyMed setid cbc8c074-f080-4489-a5ae-207b5fadeba3
- AEMPS: Ficha técnica: Bupropión (nº registro 88175), sección 4.5 (2026)– AEMPS, CIMA, nº registro 88175, revisión 03/2026, sección 4.5