MajorOther antidepressants (NDRI)×Selective estrogen receptor modulator (SERM)
Updated · Methodology
Mechanism
Bupropion is a strong CYP2D6 inhibitor. Endoxifen falls 60%.
Symptoms
Tumour progression.
Management
For smoking cessation – nicotine replacement or varenicline (not a CYP2D6 inhibitor).
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- NCCN: NCCN Guidelines for cancer prevention and risk reduction (2024)– National Comprehensive Cancer Network, 2024
- FDA: Tamoxifen citrate tablet (Mylan Pharmaceuticals Inc.) – Prescribing Information – CYP2D6 metabolism and antidepressant interactions (2018)– FDA Nolvadex label, Clinical Pharmacology §12.3 and Drug Interactions §7; DailyMed setid 7ee3d3d2-85d1-4018-8e70-5ed8a64ae1f0
- FDA: Nolvadex (tamoxifen) prescribing information (2018)
- AEMPS: Ficha técnica: Tamoxifeno (nº registro 61556), sección 4.5 (2026)– AEMPS, CIMA, nº registro 61556, revisión 05/2026, sección 4.5