Major
Bupropion × Tamoxifen
Other antidepressants (NDRI)×Selective estrogen receptor modulator (SERM)
Mechanism
Bupropion is a strong CYP2D6 inhibitor. Endoxifen falls 60%.
Symptoms
Tumour progression.
Management
For smoking cessation – nicotine replacement or varenicline (not a CYP2D6 inhibitor).
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- NCCN: NCCN Guidelines for cancer prevention and risk reduction (2024)– National Comprehensive Cancer Network, 2024
- FDA: Nolvadex (tamoxifen) prescribing information – CYP2D6 metabolism and antidepressant interactions (2018)– FDA Nolvadex label, Clinical Pharmacology §12.3 and Drug Interactions §7
- FDA: Nolvadex (tamoxifen) prescribing information (2018)