MajorSelective serotonin reuptake inhibitors×Selective estrogen receptor modulator (SERM)
Updated · Methodology
Mechanism
Fluoxetine is a strong CYP2D6 inhibitor. Endoxifen falls 60%.
Symptoms
Tumour progression on long-term use.
Management
Alternative – sertraline, escitalopram or venlafaxine.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Tamoxifen citrate tablet (Mylan Pharmaceuticals Inc.) – Prescribing Information – CYP2D6 metabolism and antidepressant interactions (2018)– FDA Nolvadex label, Clinical Pharmacology §12.3 and Drug Interactions §7; DailyMed setid 7ee3d3d2-85d1-4018-8e70-5ed8a64ae1f0
- Journal of Clinical Oncology: CYP2D6 metabolism and patient outcomes in the tamoxifen adjuvant trial (2018)– Goetz MP, Suman VJ, Hoskin TL, et al. J Clin Oncol 2018;36(16):1610-1618
- FDA: Nolvadex (tamoxifen) prescribing information (2018)
- AEMPS: Ficha técnica: Fluoxetina (nº registro 63499), sección 4.5 (2026)– AEMPS, CIMA, nº registro 63499, revisión 10/2026, sección 4.5
- AEMPS: Ficha técnica: Tamoxifeno (nº registro 61556), sección 4.5 (2026)– AEMPS, CIMA, nº registro 61556, revisión 05/2026, sección 4.5