MajorOther antidepressants (NDRI)×SNRI (serotonin-norepinephrine reuptake inhibitor)
Updated · Methodology
Mechanism
Additive seizure threshold reduction plus elevated synaptic norepinephrine. Venlafaxine prolongs QT at high doses.
Symptoms
Tachycardia, hypertension, tremor, agitation. Seizures (especially with prior epilepsy) and QT prolongation at high venlafaxine doses are possible.
Management
The combination is possible for augmentation. Cap bupropion at 300 mg and venlafaxine at 150 mg/day. ECG at 2 weeks; monitor blood pressure and pulse. Avoid with prior epilepsy.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Effexor XR (venlafaxine) prescribing information (2017)– ; DailyMed setid c848a5d8-ba94-4c84-80e3-0bf35fb8e32e
- AEMPS: Ficha técnica: Bupropión (nº registro 88175), sección 4.5 (2026)– AEMPS, CIMA, nº registro 88175, revisión 03/2026, sección 4.5