MajorOther antidepressants (NDRI)×Atypical antipsychotics
Updated · Methodology
Mechanism
Quetiapine lowers the seizure threshold, especially at doses above 300 mg/day. Bupropion is a potent proconvulsant. Additive seizure risk.
Symptoms
Seizures (generalised tonic-clonic or focal), agitation, tremor, insomnia. Patients with prior epilepsy or eating disorders are at particular risk.
Management
Avoid the combination, especially with quetiapine above 300 mg. Alternative antipsychotics: olanzapine or aripiprazole (minimal seizure threshold effect). Alternative antidepressants: sertraline or escitalopram.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Seroquel (quetiapine) prescribing information (2017)– ; DailyMed setid 8ae62aaf-f8c5-417f-baac-0098369ca322
- AEMPS: Ficha técnica: Bupropión (nº registro 88175), sección 4.5 (2026)– AEMPS, CIMA, nº registro 88175, revisión 03/2026, sección 4.5