CriticalAntiepileptics. Carboxamide derivatives×Second-generation systemic triazole antifungal
Updated · Methodology
Mechanism
Carbamazepine is a strong CYP3A4 inducer. Isavuconazole falls significantly. EMA Cresemba Section 4.3.
Symptoms
Mycosis progression.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- EMA: Cresemba (isavuconazole) SmPC (2024)– EMA EPAR Cresemba
- AEMPS: Ficha técnica: Carbamazepina (nº registro 62621), sección 4.4 (2025)– AEMPS, CIMA, nº registro 62621, revisión 06/2025, sección 4.4