Critical
Carbamazepine × Isavuconazole
Antiepileptics. Carboxamide derivatives×Second-generation systemic triazole antifungal
Mechanism
Carbamazepine is a strong CYP3A4 inducer. Isavuconazole falls significantly. EMA Cresemba Section 4.3.
Symptoms
Mycosis progression.
Management
Combination contraindicated.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Sources
- EMA: Cresemba (isavuconazole) SmPC (2024)– EMA EPAR Cresemba